Just read on Joystiq that a big budget Syndicate remake is in the works. The original was a favorite of mine on the Amiga, so I'm excited to see the news. I hope they will go in the RTS direction rather than try to make an FPS out of it; it seems to me that the original model would work quite well with just a great audiovisual makeover. It might also be nice to ratchet up the number and complexity of the options you had to modify your cyborgs--and, by all means, keep the dark and brooding ambiance.
Unfortunately, looks like we'll be waiting a long time for this one.